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Search Results for " pcsk 9 "

22

抑制剂 & 化合物

1

天然产物

21

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T39685 PCSK9 degrader 1

PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T39528 PCSK9-IN-2

PCSK9-IN-2

PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
T72025 PCSK9-IN-10

Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism
PCSK9-IN-10 是一种有效的,具有口服活性的PCSK9抑制剂,IC50值为 6.4 µM。PCSK9-IN-10 增加LDLR 蛋白的表达并降低 PCSK9 的表达。PCSK9-IN-10 可减缓动脉粥样硬化进展。PCSK9-IN-10 具有研究高脂血症的潜力。
T67776 PCSK9-IN-11

Others Others
PCSK9-IN-11 (compound 5r) 是口服有效的 PCSK9 抑制剂。 PCSK9-IN-11 在 HepG2 细胞中抑制 PCSK9 转录活性 (IC50= 5.7 μM)。 PCSK9-IN-11 可以增加 LDL 受体 (LDLR) 蛋白水平,可用于动脉粥样硬化研究。
T13813 PCSK9 ligand 1

Others Others
PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).
T79030 PCSK9-IN-14

PCSK9-IN-14 (compound Ia-8)为高效的PCSK9抑制剂。
T79052 PCSK9-IN-16

PCSK9-IN-16,有效的PCSK9抑制剂,用于治疗高胆固醇血症及其他心血管疾病。
T74167 PCSK9-IN-3

PCSK9-IN-3为新一代口服高效三环肽类PCSK9抑制剂,特征为新型化合物。
T79239 PCSK9-IN-19

PCSK9-IN-19 (Compound 1)作为一种PCSK9抑制剂,用于研究高LDL胆固醇水平及预防冠状动脉疾病。
T75147 PCSK9-IN-18

PCSK9-IN-18 (compound 188)是一种有效的 PCSK9抑制剂,KD 值为 <200 nM[1]。
T79053 PCSK9-IN-17

PCSK9-IN-17作为PCSK9抑制剂,主要应用于胆固醇代谢研究。
T79051 PCSK9-IN-15

PCSK9-IN-15(化合物5)是一种高效PCSK9抑制剂,亲和力强(KD<200 nM)。该化合物与胆固醇代谢相关,可调控低密度脂蛋白胆固醇(LDL-C)水平,适用于研究降低胆固醇及血脂异常。
T73008 PCSK9-IN-13

PCSK9-IN-13 是一种有效的PCSK9抑制剂, 可通过与 PCSK9 结合作用来拮抗低密度脂蛋白(LDL) 受体结合,其IC50值为 537 nM。
T81535 PCSK9-IN-20

PCSK9-IN-20(Compound 3i)作为一种PCSK9抑制剂,具有IC50为 3.96 µM,能有效降低体外PCSK9水平并提升LDLR蛋白表达。
T60541 PCSK9 modulator-2

PCSK9 modulator-2 (Compound 1) 是一种有效的PCSK9调节剂(EC50 = 202 nM), 具有用于高脂血症的研究潜力。PCSK9 是降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。
T60764 PCSK9 modulator-4

PCSK9 modulator-4 (Compound 21) 是可以用于高血脂研究的,PCSK9的有效调节剂 (EC 50 = 0.15 nM)。PCSK9 是得到验证的一种降低低密度脂蛋白胆固醇 (LDL-C) 的靶标。
T60646 PCSK9 modulator-3

PCSK9 modulator-3 (Compound 13) 是PCSK9的有效调节剂,EC50值为 2.46 nM,在高脂血症研究中具有潜力。PCSK9 是已证实的降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。
T76974 Tafolecimab

Tafolecimab (IBI-306) 是一种人源 lgG2 单克隆抗体,可特异性结合 PCSK-9并通过抑制 PCSK-9 介导的低密度脂蛋白受体的内吞作用降低 LDL-C 水平,进而增强对 LDL-C 的清除,导致 LDL-C 水平降低。Tafolecimab 可用于高胆固醇血症的研究。
T39122 Inclisiran

ALN-PCSsc

Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (CVD).
T74249 AS(3n-2)-Inclisiran

AS(3n-2)-Inclisiran 是 Inclisiran 的反义链,其在 2 bp 的间隔后有3n 个随机位点。Inclisiran 是一种双链小干扰 RNA (siRNA) 分子,可抑制PCSK-9的转录。
T74248 AS-Inclisiran

AS-Inclisiran为Inclisiran的反义链。Inclisiran(ALN-PCSsc)为双链小干扰RNA(siRNA)分子,目的在于抑制PCSK-9的转录,适用于高脂血症及心血管疾病(CVD)的研究。
T74876 GalNAc unconjugated/naked Inclisiran

GalNAc unconjugated/naked Inclisiran 是一种未偶联GalNAc的双链小干扰RNA (siRNA) 分子,具有抑制PCSK-9转录功能。该化合物主要应用于高脂血症及心血管疾病(CVD)的研究领域。

化合物

PCSK9 degrader 1
Cat.No: T39685
Synonym:
Target:
PCSK9-IN-2
Cat.No: T39528
Synonym: PCSK9-IN-2
Target:
PCSK9-IN-10
Cat.No: T72025
Synonym:
Target: Serine/threonin kinase
PCSK9-IN-11
Cat.No: T67776
Synonym:
Target: Others
PCSK9 ligand 1
Cat.No: T13813
Synonym:
Target: Others
PCSK9-IN-14
Cat.No: T79030
Synonym:
Target:
PCSK9-IN-16
Cat.No: T79052
Synonym:
Target:
PCSK9-IN-3
Cat.No: T74167
Synonym:
Target:
PCSK9-IN-19
Cat.No: T79239
Synonym:
Target:
PCSK9-IN-18
Cat.No: T75147
Synonym:
Target:
PCSK9-IN-17
Cat.No: T79053
Synonym:
Target:
PCSK9-IN-15
Cat.No: T79051
Synonym:
Target:
PCSK9-IN-13
Cat.No: T73008
Synonym:
Target:
PCSK9-IN-20
Cat.No: T81535
Synonym:
Target:
PCSK9 modulator-2
Cat.No: T60541
Synonym:
Target:
PCSK9 modulator-4
Cat.No: T60764
Synonym:
Target:
PCSK9 modulator-3
Cat.No: T60646
Synonym:
Target:
Tafolecimab
Cat.No: T76974
Synonym:
Target:
Inclisiran
Cat.No: T39122
Synonym: ALN-PCSsc
Target:
AS(3n-2)-Inclisiran
Cat.No: T74249
Synonym:
Target:
AS-Inclisiran
Cat.No: T74248
Synonym:
Target:
GalNAc unconjugated/naked Inclisiran
Cat.No: T74876
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T75545 PCSK9-IN-9

PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。

天然产物

PCSK9-IN-9
Cat.No: T75545
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-00483 PCSK9 Protein, Cynomolgus, Recombinant (His)

PCSK9

Cynomolgus HEK293 Cells
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
TMPJ-00443 PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Proprotein Convertase Subtilisin/Kexin Type 9,P...

Macaca nemestrina HEK293 Cells
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPJ-00368 PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Subtilisin/Kexin-Like Protease PC9,PC9,NAR...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPJ-00369 PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Subtilisin/Kexin-Like Protease PC9,PCSK

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7.
TMPY-05131 PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated

NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein convertase s...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1.
TMPY-04966 PCSK9 Protein, Human, Recombinant (D374Y, His)

LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein converta...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPY-00408 PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)

FH3,proprotein convertase subtilisin/kexin type 9,L...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
TMPY-00995 PCSK9 Protein, Rhesus, Recombinant (His)

proprotein convertase subtilisin/kexin type 9

Rhesus HEK293 Cells
PCSK9 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.7 kDa and the accession number is A8T666.
TMPY-05217 PCSK9 Protein, Mouse, Recombinant (mFc)

HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein convertase su...

Mouse HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65.
TMPY-01565 PCSK9 Protein, Rat, Recombinant (His)

proprotein convertase subtilisin/kexin type 9

Rat HEK293 Cells
PCSK9 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A6JYM6.
TMPY-01245 PCSK9 Protein, Mouse, Recombinant (His)

proprotein convertase subtilisin/kexin type 9,AI747...

Mouse HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
TMPY-05218 PCSK9 Protein, Human, Recombinant (mFc)

HCHOLA3,PC9,proprotein convertase subtilisin/kexin ...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1.
TMPY-05199 PCSK9 Protein, Human, Recombinant (D374Y, mFc)

PC9,proprotein convertase subtilisin/kexin type

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05270 PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated

FH3,NARC-1,PC9,LDLCQ1,proprotein convertase subtili...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05114 PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated

LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,proprotein conv...

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1.
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His)

VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...

Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698 VEGF121b Protein, Human, Recombinant

MVCD1,VEGF,VPF,vascular endothelial growth factor A

Human HEK293 Cells
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005 YAP1 Protein, Human, Recombinant (Isoform 9, His)

YAP1-2delta

Human P. pastoris (Yeast)
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi)

VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268 Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

NRCAML,neurofascin,NF

Human HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

PCSK9 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00483
Species: Cynomolgus
Expression System: HEK293 Cells
PCSK9 Protein, Macaca nemestrina, Recombinant (His)
Cat.No: TMPJ-00443
Species: Macaca nemestrina
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated
Cat.No: TMPJ-00368
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated
Cat.No: TMPJ-00369
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05131
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, His)
Cat.No: TMPY-04966
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)
Cat.No: TMPY-00408
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-00995
Species: Rhesus
Expression System: HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (mFc)
Cat.No: TMPY-05217
Species: Mouse
Expression System: HEK293 Cells
PCSK9 Protein, Rat, Recombinant (His)
Cat.No: TMPY-01565
Species: Rat
Expression System: HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01245
Species: Mouse
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-05218
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc)
Cat.No: TMPY-05199
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated
Cat.No: TMPY-05270
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated
Cat.No: TMPY-05114
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00865
Species: Human
Expression System: HEK293 Cells
VEGF121b Protein, Human, Recombinant
Cat.No: TMPY-03698
Species: Human
Expression System: HEK293 Cells
YAP1 Protein, Human, Recombinant (Isoform 9, His)
Cat.No: TMPH-00005
Species: Human
Expression System: P. pastoris (Yeast)
VEGF121 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00825
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00826
Species: Human
Expression System: HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05268
Species: Human
Expression System: HEK293 Cells
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